Last update
5/26/2026
Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
USERS' SCORE
Good
Based on 3 Reviews
8.2
Supplement Facts
Serving Size: 3 Veg Capsules
Amount Per Serving
%DV
Calories
5
Total Carbohydrate
1.5 g
<1%**
Total Sugars
1.5 g
†
D-Mannose
1.5 g (1,500 mg)
†
Top Medical Research Studies
8
We explored the impact of D-mannose on intervertebral disc degeneration (IVDD), a condition often accompanied by significant pain. The study utilized various sophisticated methods to demonstrate that D-mannose acts primarily through a gene called TXNIP, which influences glutamine metabolism.
Though our findings suggest that D-mannose has promise in alleviating IVDD’s symptoms, we also acknowledge that it has not shown significant pain-relieving effects compared to traditional treatments. Further research may be needed to fully understand its therapeutic potential for pain management.
Though our findings suggest that D-mannose has promise in alleviating IVDD’s symptoms, we also acknowledge that it has not shown significant pain-relieving effects compared to traditional treatments. Further research may be needed to fully understand its therapeutic potential for pain management.
Read More
Most Useful Reviews
9
Relieves bone pain
4 people found this helpful
After a problematic gynaecological exam in Norway, I developed issues including bone pain and was diagnosed with cystitis. I tried antibiotics, but they only helped temporarily. However, after taking D-Mannose for three days, I could finally sleep through the night without needing to urinate, and after a week, all my symptoms, including the bone pain, vanished. If I stop taking D-Mannose, the symptoms do return.
Read More
9
Relieved bone pain
2 people found this helpful
I took two capsules three times a day alongside cranberry extract for my lower back pain that troubled me for years. I am very thankful for this product and was pleasantly surprised by the results. I will definitely repeat the course.
Read More
4
Back pain worsened
4 people found this helpful
I initially ordered this to treat my UTI, which it did successfully. However, after recurring issues and pain that left me barely able to move, I discovered that the D Mannose might cause discomfort for some. Despite treating my UTI with this product, I now experience significant back pain. I believe it is crucial for users to be cautious of potential side effects.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 1 Research
8
- All Researches
8
We explored the impact of D-mannose on intervertebral disc degeneration (IVDD), a condition often accompanied by significant pain. The study utilized various sophisticated methods to demonstrate that D-mannose acts primarily through a gene called TXNIP, which influences glutamine metabolism.
Though our findings suggest that D-mannose has promise in alleviating IVDD’s symptoms, we also acknowledge that it has not shown significant pain-relieving effects compared to traditional treatments. Further research may be needed to fully understand its therapeutic potential for pain management.
Though our findings suggest that D-mannose has promise in alleviating IVDD’s symptoms, we also acknowledge that it has not shown significant pain-relieving effects compared to traditional treatments. Further research may be needed to fully understand its therapeutic potential for pain management.
Read More
User Reviews
USERS' SCORE
Good
Based on 3 Reviews
8.2
- All Reviews
- Positive Reviews
- Negative Reviews
9
Relieves bone pain
4 people found this helpful
After a problematic gynaecological exam in Norway, I developed issues including bone pain and was diagnosed with cystitis. I tried antibiotics, but they only helped temporarily. However, after taking D-Mannose for three days, I could finally sleep through the night without needing to urinate, and after a week, all my symptoms, including the bone pain, vanished. If I stop taking D-Mannose, the symptoms do return.
Read More
9
Relieved bone pain
2 people found this helpful
I took two capsules three times a day alongside cranberry extract for my lower back pain that troubled me for years. I am very thankful for this product and was pleasantly surprised by the results. I will definitely repeat the course.
Read More
4
Back pain worsened
4 people found this helpful
I initially ordered this to treat my UTI, which it did successfully. However, after recurring issues and pain that left me barely able to move, I discovered that the D Mannose might cause discomfort for some. Despite treating my UTI with this product, I now experience significant back pain. I believe it is crucial for users to be cautious of potential side effects.
Read More
Frequently Asked Questions
9
Relieves bone pain
4 people found this helpful
After a problematic gynaecological exam in Norway, I developed issues including bone pain and was diagnosed with cystitis. I tried antibiotics, but they only helped temporarily. However, after taking D-Mannose for three days, I could finally sleep through the night without needing to urinate, and after a week, all my symptoms, including the bone pain, vanished. If I stop taking D-Mannose, the symptoms do return.
9
Relieved bone pain
2 people found this helpful
I took two capsules three times a day alongside cranberry extract for my lower back pain that troubled me for years. I am very thankful for this product and was pleasantly surprised by the results. I will definitely repeat the course.
8
We explored the impact of D-mannose on intervertebral disc degeneration (IVDD), a condition often accompanied by significant pain. The study utilized various sophisticated methods to demonstrate that D-mannose acts primarily through a gene called TXNIP, which influences glutamine metabolism.
Though our findings suggest that D-mannose has promise in alleviating IVDD’s symptoms, we also acknowledge that it has not shown significant pain-relieving effects compared to traditional treatments. Further research may be needed to fully understand its therapeutic potential for pain management.
Though our findings suggest that D-mannose has promise in alleviating IVDD’s symptoms, we also acknowledge that it has not shown significant pain-relieving effects compared to traditional treatments. Further research may be needed to fully understand its therapeutic potential for pain management.
References
- Dong ZL, Jiao X, Wang ZG, Yuan K, Yang YQ, et al. D-mannose alleviates intervertebral disc degeneration through glutamine metabolism. Mil Med Res. 2024;11:28. 10.1186/s40779-024-00529-4
